Proton pump inhibitors (PPIs) have shown great success in treating acid-related gastrointestinal diseases. PPIs are now considered the drug of choice in managing patients with peptic ulcer diseases, gastro oesophageal reflux disease and Zollinger-Elison Syndrome. Rabeprazole is a new PPI and is found to have most potent gastric acid suppression as compared to other PPIs like pantoprazole, lansoprazole and omeprazole.
Rabeprazole is not only the most potent but also has a significant quicker onset of acid inhibition. Rabeprazole also maintains the highest median pH values during the first 24 hrs & also pH>3 for higher time. Rebeprazole is superior to other PPIs with more consistent and prolonged acid inhibition. Rebeprazole has been found to be effective in treating patients of long term GERD healing maintenance, duodenal & gastric ulcers.
Rebeprazole is found to have activity against H.pylori. In comparative trials, it is found to be more superior to ranitidine. Rebeprazole scores over other PPI due to its quicker onset of action and superior relief. Rebeprazole is available in convenient once daily dosing schedule and has tolerability similar to other PPIs. Rebeprazole is safer as compared to other PPIs as it is not metabolized by cytochrome P450, where most of the drugs are metabolized.
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